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Exercise and Transcranial Magnetic Stimulation: Increasing Brain Plasticity in Parkinson's Disease

NCT02741765 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2019-07-16

No results posted yet for this study

Summary

This is a feasibility and exploratory study consisting of two parts: first, a cross-sectional (one-time) biomarker measurement comparing BDNF-TrkB (Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB,) signaling and cortical plasticity in patients diagnosed with Parkinson's Disease (PD) vs. healthy controls matched by age. Second, a prospective, randomized, double blind trial of Transcranial Magnetic Stimulation (TMS) MAGSTIM Rapid2 Therapy System (TMS) (real or Sham) and aerobic exercise. This exploratory feasibility study will look at BDNF-TrkB signaling and cortical plasticity.

Conditions

  • Parkinson Disease

Interventions

BEHAVIORAL

Sham rTMS

Subjects will participate in daily sessions of sham-rTMS

OTHER

Real rTMS

Subjects will participate in a combination of rTMS

BEHAVIORAL

Supervised aerobic exercise

Sponsors & Collaborators

Principal Investigators

  • Milton Biagioni, MD · New York University Medical School

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
35 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-11-30
Primary Completion
2018-01-26
Completion
2018-01-26

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02741765 on ClinicalTrials.gov