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Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx

NCT02739958 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2020-09-22

No results posted yet for this study

Summary

The aim of this prospective, randomized clinical study is to compare between propofol and isoflurane on perioperative immune cell populations and function in patients undergoing total laryngectomy surgery.

Conditions

  • Cancer Larynx
  • Total Laryngectomy

Interventions

DRUG

Propofol group

Anesthesia is maintained with continuous infusion of propofol 1.5-2mg/kg/h and dexmedetomidine 0.2-1ug/kg/h.

DRUG

Isoflurane group

Anesthesia was maintained with isoflurane at a concentration of 2-2.5%. fentanyl 50 ug increments

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Reem A El Sharkawy, MD · Lecturer of Anesthesia and Surgical Intensive Care

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-01
Primary Completion
2016-08-30
Completion
2016-10-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02739958 on ClinicalTrials.gov