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Postoperative Gastrointestinal Dysfunction After Cardiac Surgery - Occurrence and Search for Biomarkers

NCT02732301 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 501

Last updated 2021-03-10

No results posted yet for this study

Summary

The purpose of this study is to investigate the frequency and grade of gastrointestinal dysfunction in patients after thoracic cardiovascular surgery, and to search for biomarkers of gastrointestinal dysfunction. All adult patients undergoing elective cardiac surgery requiring cardiopulmonary bypass at Örebro University Hospital, Örebro, Sweden, are asked for participation in this study. All participating patients sign informed consent at the inclusion. The first three postoperative days the function of the gastrointestinal tract is scored according to a rating scale (grade 0-4), along with other clinical parameters. Plasma blood samples are collected from each patient preoperatively and the first three postoperative days. The plasma samples are stored in a biobank for later determination of plasma proteins. In the analysis, the patients are divided according to the gastrointestinal rating scale and the plasma protein expression, gastrointestinal complications and all-cause mortality are compared between the groups.

Conditions

  • Thoracic Surgical Procedures
  • Gastrointestinal Tract
  • Cardiopulmonary Bypass
  • Biomarkers

Sponsors & Collaborators

  • Region Örebro County

    lead OTHER

Principal Investigators

  • Kristofer F Nilsson, MD, PhD · Department of Cardio-Thoracic and Vascular Surgery, Örebro University Hospital, Örebro, SWEDEN

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-11-30
Primary Completion
2017-10-31
Completion
2022-12-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02732301 on ClinicalTrials.gov