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The Importance of Albumin Infusion Rate for Plasma Volume Expansion Following Major Abdominal Surgery

NCT02728921 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2017-04-19

No results posted yet for this study

Summary

To study if plasma volume expansion is influenced by the rate at which a colloidal solution is administered in patients with a systemic inflammatory response induced by major abdominal surgery.

Randomization will be performed postoperatively at the day of surgery with a 1:1 ratio with no stratification and the study drug will be given as a slow (3 hours) or rapid (30 minutes) intravenous infusion.

Conditions

  • Pancreatic Neoplasms
  • Urogenital Neoplasm
  • Systemic Inflammatory Response Syndrome
  • Hypovolemia

Interventions

DRUG

5% Albumin infusion 30 min

Intravenous infusion of 5% Albumin at a dose of 10 ml/kg during 30 minutes. Dose is based on ideal weight.

DRUG

5% Albumin infusion 3 hours

Intravenous infusion of 5% Albumin at a dose of 10 ml/kg during 3 hours. Dose is based on ideal weight.

Sponsors & Collaborators

  • Region Skane

    lead OTHER

Principal Investigators

  • Peter Bentzer, MD · Region Skåne

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-04-30
Primary Completion
2016-10-31
Completion
2016-11-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02728921 on ClinicalTrials.gov