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Volume Kinetics for 20% Albumin in Different Clinical Situations

NCT02556580 · Status: UNKNOWN · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2018-03-20

No results posted yet for this study

Summary

The study aims to determine the degree of plasma volume expansion and the half-life of the plasma volume expansion when 3 mL/kg of hyperoncotic (20%) albumin if infused over 30 minutes in conscious healthy volunteers, in patients undergoing surgery under general anesthesia, and on the day after major surgery when the patient is in a post surgical inflammatory state. The study also examines the increase in the plasma colloid osmotic pressure as a result of this infusion and its possible influence on markers of kidney damage.

Conditions

Interventions

DRUG

Albumin 20%

Intervention: intravenious infusion Drug: albumin

Sponsors & Collaborators

  • University Hospital, Linkoeping

    collaborator OTHER

  • Karolinska University Hospital

    collaborator OTHER

  • Sodertalje Hospital

    lead OTHER

Principal Investigators

  • Robert G Hahn, MD, PhD · Research Director, Södertälje sjukhus

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-02-29
Primary Completion
2018-12-31
Completion
2019-04-01

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02556580 on ClinicalTrials.gov