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Genotypes and Phenotypes in Pediatric SIRS and Sepsis

NCT02728401 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 104

Last updated 2018-04-19

No results posted yet for this study

Summary

The aim of this investigation is to longitudinally quantify host gene expression and serum proteins in children with infectious and non-infectious SIRS. The investigators hypothesize that children with non-infectious SIRS, with bacterial infection associated SIRS, or with viral infection associated SIRS will exhibit distinct patterns of host gene expression and serum proteins. The investigators further hypothesize that it should be possible to discover sets of mRNA or protein biomarkers that will permit unambiguous diagnosis of non-infectious SIRS, SIRS associated with bacterial infection, and SIRS associated with viral infection.

Conditions

  • Systemic Inflammatory Response Syndrome (SIRS)
  • Sepsis

Sponsors & Collaborators

  • Immunexpress

    collaborator INDUSTRY

  • Seattle Children's Hospital

    lead OTHER

Principal Investigators

  • Jerry J Zimmerman, MD, PhD · Seattle Children's Hospital

Eligibility

Min Age
38 Weeks
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-05-01
Primary Completion
2017-12-31
Completion
2017-12-31

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02728401 on ClinicalTrials.gov