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Host-pathogen Interactions in Meningococcal Disease: Finding the Key That Fits the Lock

NCT02727465 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2017-04-05

No results posted yet for this study

Summary

At any time, around 10% of people carry meningococcal bacteria in the nose and throat, which can cause meningitis, blood poisoning and other serious illnesses. Most people carry these bacteria and never become ill, yet a very small proportion go on to develop these illnesses which can result in life long disabilities or death. The mechanism by which this happens is poorly understood and has been studied in various ways, usually focussing on the bacteria or on the individual, but none has given a definitive answer. This study will be the first of its kind and will assess the interaction between the host and the bacteria at the genetic level, through genetic mapping, helping us to understand what makes some people susceptible to this infection.

Conditions

Interventions

OTHER

Meningitis cases

None - blood draw only

Sponsors & Collaborators

  • Public Health England

    lead OTHER_GOV

Principal Investigators

  • Shamez Ladhani, MD PhD · Public Health England

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • United Kingdom

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02727465 on ClinicalTrials.gov