Trial Outcomes & Findings for Medium Chain Triglycerides and Aerobic Exercise on Ketone Production in Women With or Without Prediabetes (NCT NCT02678390)
NCT ID: NCT02678390
Last Updated: 2020-04-07
Results Overview
Acetoacetate (umol/L) and beta-hydroxybutyrate (umol/L); Called Ketones (µmol/L) when combine together The area under the curve (AUC) was calculated according to the trapezoidal method from 0 to 4 h during the visits (interventions) CTL = Metabolic study day (Day 1) MCT = Metabolic study day after 5 days of supplementation (Day 5) AE= Metabolic Study day after acute aerobic exercise (Day 6) AE + MCT = Metabolic Study day after 5 days of aerobic exercise and mct supplementation (Day 11)
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
20 participants
Primary outcome timeframe
5 days
Results posted on
2020-04-07
Participant Flow
Participant milestones
| Measure |
Healthy Women
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
Control (5 Days)
STARTED
|
10
|
10
|
|
Control (5 Days)
COMPLETED
|
10
|
10
|
|
Control (5 Days)
NOT COMPLETED
|
0
|
0
|
|
MCT (5 Days)
STARTED
|
10
|
10
|
|
MCT (5 Days)
COMPLETED
|
10
|
10
|
|
MCT (5 Days)
NOT COMPLETED
|
0
|
0
|
|
AE (1 Day)
STARTED
|
10
|
10
|
|
AE (1 Day)
COMPLETED
|
10
|
9
|
|
AE (1 Day)
NOT COMPLETED
|
0
|
1
|
|
MCT + AE (5 Days)
STARTED
|
10
|
9
|
|
MCT + AE (5 Days)
COMPLETED
|
10
|
9
|
|
MCT + AE (5 Days)
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
| Measure |
Healthy Women
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
AE (1 Day)
Withdrawal by Subject
|
0
|
1
|
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Healthy Women
n=10 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
n=9 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Total
n=19 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
67 years
STANDARD_DEVIATION 4 • n=10 Participants
|
68 years
STANDARD_DEVIATION 5 • n=9 Participants
|
68 years
STANDARD_DEVIATION 4 • n=19 Participants
|
|
Sex: Female, Male
Female
|
10 Participants
n=10 Participants
|
9 Participants
n=9 Participants
|
19 Participants
n=19 Participants
|
|
Sex: Female, Male
Male
|
0 Participants
n=10 Participants
|
0 Participants
n=9 Participants
|
0 Participants
n=19 Participants
|
|
Race and Ethnicity Not Collected
|
—
|
—
|
0 Participants
Race and Ethnicity were not collected from any participant.
|
|
Region of Enrollment
Canada
|
10 participants
n=10 Participants
|
9 participants
n=9 Participants
|
19 participants
n=19 Participants
|
|
Body mass index
|
27 kg/m2
STANDARD_DEVIATION 3 • n=10 Participants
|
28 kg/m2
STANDARD_DEVIATION 4 • n=9 Participants
|
27 kg/m2
STANDARD_DEVIATION 4 • n=19 Participants
|
|
Total body fat
|
43 % of body fat
STANDARD_DEVIATION 6 • n=10 Participants
|
40 % of body fat
STANDARD_DEVIATION 4 • n=9 Participants
|
42 % of body fat
STANDARD_DEVIATION 5 • n=19 Participants
|
|
Plasma glucose
|
5.4 mmol/L
STANDARD_DEVIATION 0.1 • n=10 Participants
|
6.1 mmol/L
STANDARD_DEVIATION 0.4 • n=9 Participants
|
5.8 mmol/L
STANDARD_DEVIATION 0.3 • n=19 Participants
|
|
Glycated hemoglobin
|
5.7 % of glycated hemoglobin
STANDARD_DEVIATION 0.2 • n=10 Participants
|
6.1 % of glycated hemoglobin
STANDARD_DEVIATION 0.2 • n=9 Participants
|
5.9 % of glycated hemoglobin
STANDARD_DEVIATION 0.2 • n=19 Participants
|
|
Ketones
|
153 µmol/L
STANDARD_DEVIATION 94 • n=10 Participants
|
116 µmol/L
STANDARD_DEVIATION 71 • n=9 Participants
|
135 µmol/L
STANDARD_DEVIATION 83 • n=19 Participants
|
|
Triglycerides
|
1.5 mmol/L
STANDARD_DEVIATION 0.4 • n=10 Participants
|
1.6 mmol/L
STANDARD_DEVIATION 0.8 • n=9 Participants
|
1.55 mmol/L
STANDARD_DEVIATION 0.6 • n=19 Participants
|
|
Free Fatty acids
|
0.8 mmol/L
STANDARD_DEVIATION 0.3 • n=10 Participants
|
0.7 mmol/L
STANDARD_DEVIATION 0.3 • n=9 Participants
|
0.75 mmol/L
STANDARD_DEVIATION 0.3 • n=19 Participants
|
|
Insulin
|
64 pmol/L
STANDARD_DEVIATION 11 • n=10 Participants
|
65 pmol/L
STANDARD_DEVIATION 32 • n=9 Participants
|
64.5 pmol/L
STANDARD_DEVIATION 22 • n=19 Participants
|
PRIMARY outcome
Timeframe: 5 daysAcetoacetate (umol/L) and beta-hydroxybutyrate (umol/L); Called Ketones (µmol/L) when combine together The area under the curve (AUC) was calculated according to the trapezoidal method from 0 to 4 h during the visits (interventions) CTL = Metabolic study day (Day 1) MCT = Metabolic study day after 5 days of supplementation (Day 5) AE= Metabolic Study day after acute aerobic exercise (Day 6) AE + MCT = Metabolic Study day after 5 days of aerobic exercise and mct supplementation (Day 11)
Outcome measures
| Measure |
Healthy Women
n=10 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
n=9 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
Plasma Ketone Concentrations
CTL: AUC ketone
|
-52 (µmol/h)/L
Standard Deviation 117
|
12 (µmol/h)/L
Standard Deviation 96
|
|
Plasma Ketone Concentrations
MCT: AUC ketone
|
493 (µmol/h)/L
Standard Deviation 243
|
627 (µmol/h)/L
Standard Deviation 489
|
|
Plasma Ketone Concentrations
AE: AUC ketone
|
122 (µmol/h)/L
Standard Deviation 146
|
23 (µmol/h)/L
Standard Deviation 74
|
|
Plasma Ketone Concentrations
MCT+AE: AUC ketone
|
835 (µmol/h)/L
Standard Deviation 444
|
663 (µmol/h)/L
Standard Deviation 417
|
SECONDARY outcome
Timeframe: 5 daysGlucose (mmol/L) measured in the plasma The area under the curve (AUC) was calculated according to the trapezoidal method from 0 to 4 h during the visits (interventions) CTL = Metabolic study day (Day 1) MCT = Metabolic study day after 5 days of supplementation (Day 5) AE= Metabolic Study day after acute aerobic exercise (Day 6) AE + MCT = Metabolic Study day after 5 days of aerobic exercise and mct supplementation (Day 11)
Outcome measures
| Measure |
Healthy Women
n=10 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
n=9 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
Plasma Glucose Concentrations
CTL: AUC glucose
|
7.6 (mmol*h)/L
Standard Deviation 1.4
|
11.0 (mmol*h)/L
Standard Deviation 2.8
|
|
Plasma Glucose Concentrations
MCT: AUC glucose
|
7.3 (mmol*h)/L
Standard Deviation 1.3
|
11.6 (mmol*h)/L
Standard Deviation 2.8
|
|
Plasma Glucose Concentrations
AE: AUC glucose
|
7.6 (mmol*h)/L
Standard Deviation 1.0
|
10.4 (mmol*h)/L
Standard Deviation 3.0
|
|
Plasma Glucose Concentrations
MCT+AE: AUC glucose
|
7.7 (mmol*h)/L
Standard Deviation 1.5
|
10.3 (mmol*h)/L
Standard Deviation 1.8
|
SECONDARY outcome
Timeframe: 5 daysTriglycerides (mmol/L) measured in the plasma The area under the curve (AUC) was calculated according to the trapezoidal method from 0 to 4 h during the visits (interventions) CTL = Metabolic study day (Day 1) MCT = Metabolic study day after 5 days of supplementation (Day 5) AE= Metabolic Study day after acute aerobic exercise (Day 6) AE + MCT = Metabolic Study day after 5 days of aerobic exercise and mct supplementation (Day 11)
Outcome measures
| Measure |
Healthy Women
n=10 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
n=9 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
Plasma Triglyceride Concentrations
CTL: AUC triglycerides
|
3.6 (mmol*h)/L
Standard Deviation 0.6
|
3.8 (mmol*h)/L
Standard Deviation 0.3
|
|
Plasma Triglyceride Concentrations
MCT: AUC triglycerides
|
3.9 (mmol*h)/L
Standard Deviation 0.4
|
3.5 (mmol*h)/L
Standard Deviation 0.5
|
|
Plasma Triglyceride Concentrations
AE: AUC triglycerides
|
4.0 (mmol*h)/L
Standard Deviation 0.4
|
3.7 (mmol*h)/L
Standard Deviation 0.7
|
|
Plasma Triglyceride Concentrations
MCT+AE: AUC triglycerides
|
3.9 (mmol*h)/L
Standard Deviation 0.6
|
3.5 (mmol*h)/L
Standard Deviation 0.8
|
SECONDARY outcome
Timeframe: 5 daysFree fatty acids (mmol/L) measured in the plasma The area under the curve (AUC) was calculated according to the trapezoidal method from 0 to 4 h during the visits (interventions) CTL = Metabolic study day (Day 1) MCT = Metabolic study day after 5 days of supplementation (Day 5) AE= Metabolic Study day after acute aerobic exercise (Day 6) AE + MCT = Metabolic Study day after 5 days of aerobic exercise and mct supplementation (Day 11)
Outcome measures
| Measure |
Healthy Women
n=10 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
n=9 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
Plasma Free Fatty Acid Concentrations
CTL: AUC Free fatty acids
|
1.3 (mmol*h)/L
Standard Deviation 0.3
|
1.3 (mmol*h)/L
Standard Deviation 0.6
|
|
Plasma Free Fatty Acid Concentrations
MCT: AUC Free fatty acids
|
1.3 (mmol*h)/L
Standard Deviation 0.2
|
1.5 (mmol*h)/L
Standard Deviation 0.4
|
|
Plasma Free Fatty Acid Concentrations
AE: AUC Free fatty acids
|
1.3 (mmol*h)/L
Standard Deviation 0.2
|
1.4 (mmol*h)/L
Standard Deviation 0.3
|
|
Plasma Free Fatty Acid Concentrations
MCT+AE: AUC Free fatty acids
|
1.4 (mmol*h)/L
Standard Deviation 0.6
|
1.6 (mmol*h)/L
Standard Deviation 0.3
|
SECONDARY outcome
Timeframe: 5 daysInsulin (nmol/L) measured in the plasma The area under the curve (AUC) was calculated according to the trapezoidal method from 0 to 4 h during the visits (interventions) CTL = Metabolic study day (Day 1) MCT = Metabolic study day after 5 days of supplementation (Day 5) AE= Metabolic Study day after acute aerobic exercise (Day 6) AE + MCT = Metabolic Study day after 5 days of aerobic exercise and mct supplementation (Day 11)
Outcome measures
| Measure |
Healthy Women
n=10 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
Women With Prediabetes
n=9 Participants
Arm: Evaluation of MCT, aerobic exercise alone and MCT+ aerobic exercise on glucose/ketone/lipid/insulin metabolism in 4-hour visits with repeated blood sampling.
Interventions:
1. A control day with no MCT and no aerobic exercise.
2. A 5 day consecutive MCT intake of 30 g/day.
3. 30 minutes of aerobic exercise at 70% to 80% HRR of intensity.
4. A 5 day consecutive MCT intake of 30 g/day in combination with 30 minutes of aerobic exercise (70% to 80% HRR)/ day for the five days.
MCT: A 5 day consecutive MCT intake of 30 g/day.
MCT+ aerobic exercise: A 5 day consecutive MCT intake of 30 g/day in combinaison with 30 minutes of aerobic exercise (70% to 80% HRR) per day for the five days.
Aerobic exercise: A single period of 30 minutes of aerobic exercise (70% to 80% HRR).
Control day: No MCT or aerobic exercise
|
|---|---|---|
|
Plasma Insulin Concentrations
CTL: AUC Insulin
|
0.9 (nmol*h)/L
Standard Deviation 0.5
|
0.8 (nmol*h)/L
Standard Deviation 0.3
|
|
Plasma Insulin Concentrations
MCT: AUC Insulin
|
0.8 (nmol*h)/L
Standard Deviation 0.3
|
0.8 (nmol*h)/L
Standard Deviation 0.8
|
|
Plasma Insulin Concentrations
AE: AUC Insulin
|
0.8 (nmol*h)/L
Standard Deviation 0.2
|
0.7 (nmol*h)/L
Standard Deviation 0.3
|
|
Plasma Insulin Concentrations
MCT+AE: AUC Insulin
|
0.7 (nmol*h)/L
Standard Deviation 0.3
|
0.6 (nmol*h)/L
Standard Deviation 0.2
|
Adverse Events
Healthy Women
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Women With Prediabetes
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place