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Shifting Pain Modulation From Pro-to Anti-nociceptive

NCT02672202 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2017-09-28

No results posted yet for this study

Summary

To create a data base that will facilitate the enrichment of the insights regarding post-operative pain development, and to identify those individuals with the potential to develop this kind of pain. The identification will be based on the individualized pain modulation profile, composed of a battery of tests as detailed below.

Conditions

  • Post-operative Chronic Pain

Interventions

DRUG

Duloxetine

* 60 mg/d - twice before surgery and once a day for post operative days 3-7 * 30 mg/d - once a day for post operative days 1-2

DRUG

Pregabalin

* 75 mg/d - twice a day for post operative days 1-2 * 150 mg/d - twice a day for post operative days 3-7 300 mg/d - twice before surgery

DRUG

Placebo

* non-active - twice before surgery * non-active - twice a day for post operative days 1-7

Sponsors & Collaborators

  • Rambam Health Care Campus

    lead OTHER

Principal Investigators

  • David Yarnitsky · Head of Neurology department at Rambam

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-02-29
Primary Completion
2017-05-31
Completion
2017-05-31

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Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02672202 on ClinicalTrials.gov