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Can Postprandial Reactive Hypoglycaemia be Reduced in Patients After Roux-en-Y Gastric Bypass With a Low Carbohydrate Diet?

NCT02665715 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2016-07-21

No results posted yet for this study

Summary

Roux-en-Y gastric bypass (RYGB) accelerates nutrient delivery to the small intestine causing higher peak blood glucose concentration early after meal intake. In the late postprandial period (1 1⁄2-2 h) nadir blood glucose level is lower compared with before operation. In some patients, overt postprandial hypoglycaemia develops, and is typically reported as a complication 1-5 years postoperatively, when maximal weight loss has been obtained. The pathophysiology of postprandial hypoglycaemia involves inappropriate hyper-secretion of insulin associated with exaggerated secretion of the gut hormone glucagon-like peptide-1 (GLP-1) leading to a mismatch between glucose absorption rate, insulin secretion and whole body glucose disposal. We hypothesize that lowering carbohydrate content of meals reduces postprandial glucose excursions whereby GLP-1 and insulin secretion is reduced and reactive hypoglycemia prevented.

Conditions

  • Bariatric Surgery (Gastric Bypass)

Interventions

OTHER

Low carbohydrate meals

Meal macronutritional energy composition: Carbohydrate 30% Protein 30% Fat 40%

OTHER

Standard carbohydrate meals

Meal macronutritional energy composition: Carbohydrate 55% Protein 15% Fat 30%

Sponsors & Collaborators

  • Hvidovre University Hospital

    collaborator OTHER

  • Amirsalar Samkani

    lead OTHER

Principal Investigators

  • Kirstine Bojsen-Moller, MD, Postdoc · Hvidovre University Hospital

  • Sten Madsbad, MD, Prof · Hvidovre University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
25 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2016-06-30
Completion
2016-06-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02665715 on ClinicalTrials.gov