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Muscle Connective Tissue in Limb Development and Disease

NCT02611089 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2025-08-27

No results posted yet for this study

Summary

The objective of this work is to understand how the disruption of the muscle connective tissue contributes to the limb soft-tissue defects in radial dysplasia. In parallel, the researchers will investigate the role of muscle connective tissue in normal limb development.

Conditions

  • Radial Dysplasia

Interventions

PROCEDURE

Tissue biopsy

Sampling of tissue as described.

Sponsors & Collaborators

  • Great Ormond Street Hospital for Children NHS Foundation Trust

    collaborator OTHER

  • Royal Free Hospital NHS Foundation Trust

    collaborator OTHER

  • Chelsea and Westminster NHS Foundation Trust

    collaborator OTHER

  • King's College London

    lead OTHER

Principal Investigators

  • Malcolm Logan, PhD · King's College London

  • Branavan Sivakumar, FRCS(Plast) · Great Ormond Street Hospital for Children NHS Foundation Trust

  • Gill Smith, FRCS(Plast) · Great Ormond Street Hospital for Children NHS Foundation Trust

  • George Murphy, PhD FRCS · Great Ormond Street Hospital for Children NHS Foundation Trust

  • Lucy Cogswell, FRCS(Plas) · Oxford University Hospitals

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-20
Primary Completion
2026-02-01
Completion
2036-08-31

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02611089 on ClinicalTrials.gov