A Phase 1/2 Study of MEDI4276 in Adults Subjects With Select HER2-expressing Advanced Solid Tumors.
NCT02576548 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 47
Last updated 2019-06-18
Summary
This research study is designed to evaluate an experimental drug, MEDI4276, in treating breast and stomach (gastric) cancer.
Conditions
- HER2 Expressing Breast or Gastric/Stomach Cancers
Interventions
- BIOLOGICAL
-
MEDI4276
MEDI4276 is an investigational product
Sponsors & Collaborators
-
MedImmune LLC
lead INDUSTRY
Principal Investigators
-
MedImmune LLC · Sponsor GmbH
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 99 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-09-23
- Primary Completion
- 2018-05-23
- Completion
- 2018-05-23
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Radiation, Chemotherapy, Vaccine and Anti-MART-1 and Anti-gp100 Cells for Patients With Metastatic Melanoma
NCT00923195 ·Status: COMPLETED ·Phase: PHASE2
-
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
NCT03412877 ·Status: RECRUITING ·Phase: PHASE2
-
Vaccine Therapy in Treating Patients With Metastatic Solid Tumors
NCT01376505 ·Status: COMPLETED ·Phase: PHASE1
-
A Dose-escalation Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-573 in Subjects With Advanced Solid Tumors
NCT00816361 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase 1 Study to Evaluate MEDI6383 Alone and in Combination With MEDI4736 in Adult Subjects With Select Advanced Solid Tumors
NCT02221960 ·Status: COMPLETED ·Phase: PHASE1
-
CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer
NCT01583686 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
NCT04119024 ·Status: RECRUITING ·Phase: PHASE1
-
A Dose Escalation, Dose Expansion Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-575, in Subjects With Advanced Tumors.
NCT00816400 ·Status: COMPLETED ·Phase: PHASE1
-
Prospective Randomized Study of Cell Transfer Therapy for Metastatic Melanoma Using Tumor Infiltrating Lymphocytes Plus IL-2 Following Non-Myeloablative Lymphocyte Depleting Chemo Regimen Alone or in Conjunction With 12Gy Total Body Irradiation (TBI...
NCT01319565 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
NCT05877599 ·Status: RECRUITING ·Phase: PHASE1
-
Immunotherapy in Treating Patients With Metastatic Breast Cancer
NCT00003432 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Mesothelin-targeted CAR T-cell Therapy in Patients With Mesothelioma
NCT04577326 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Memory-Like Natural Killer Cells With Nivolumab and Relatlimab in Advanced or Metastatic Melanoma After Progression on Checkpoint Inhibitors
NCT05629546 ·Status: RECRUITING ·Phase: PHASE1
-
Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer
NCT05098210 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer
NCT06623396 ·Status: RECRUITING ·Phase: PHASE1
-
TRAIL-R2 and HER2 Bi-Specific Chimeric Antigen Receptor (CAR) T Cells for the Treatment of Metastatic Breast Cancer
NCT06251544 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Tumor Cell Vaccine in Treating Patients With Advanced Cancer
NCT00002505 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of MEDI5395 in Combination With Durvalumab in Participants With Select Advanced Solid Tumors
NCT03889275 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy in Treating Patients With Stage IV Hormone Receptor Positive Breast Cancer
NCT01729884 ·Status: TERMINATED ·Phase: PHASE2
-
Evaluating the T Cell Response to a Peptide-based Vaccine in Patients With Breast Cancer
NCT00892567 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of MEDI9197 in Subjects With Solid Tumors or CTCL and in Combination With Durvalumab and/or Palliative Radiation in Subjects With Solid Tumors
NCT02556463 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab
NCT02621021 ·Status: RECRUITING ·Phase: PHASE2
-
Immunotherapy Combination: Irradiated PD-L1 CAR-NK Cells Plus Pembrolizumab Plus N-803 for Subjects With Recurrent/Metastatic Gastric or Head and Neck Cancer
NCT04847466 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
NCT06885697 ·Status: RECRUITING ·Phase: PHASE1
-
Laboratory-Treated T Cells and Ipilimumab in Treating Patients With Metastatic Melanoma
NCT00871481 ·Status: COMPLETED ·Phase: PHASE1/PHASE2