Demodex Density, Immune Response and Oxidative Stress in Rosacea Patients

Summary

Aim of study is to determine reactive oxygen products and antioxidant capacity with rosacea patients; to measure metalloproteinase level and inflammatory markers of immune response and investigate their corelation with demodex infestation and also investigate the role of photoaging and sebum secretion in rosacea.

Conditions

• Rosacea

Interventions

OTHER

Obtaining a blood sample

Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), paraoxonase-1 (PON-1), aryl esterase (ARES), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-9 (MMP-9) levels in venous blood were measured.

DEVICE

Reflectance confocal microscopy

1mm2-sized 10 images were taken from right cheek and forehead; the number of demodex, follicle, the number of mite per follicle, the number of infested follicle and the number of mite per infested follicle were calculated with RCM. And photoaging severity were also assessed by using RCM.

DEVICE

Sebumeter

Sebum rate at forehead and right cheek were evaluated with sebumeter

DEVICE

Video dermoscopy

Dermoscopic photoaging scale were assessed by using video dermoscopy.

Sponsors & Collaborators

• Bezmialem Vakif University

  collaborator OTHER

• Istanbul Training and Research Hospital

  lead OTHER_GOV

Principal Investigators

• Tugba Falay · Istanbul Training and Research Hospital

• Vefa Aslı Erdemir · Istanbul Training and Research Hospital

• Mehmet Salih Gürel · Istanbul Training and Research Hospital

• Abdurrahim Kocyigit · Bezmialem Vakif University

• Duygu Erdil · Istanbul Training and Research Hospital

• Eray Metin Güler · Bezmialem Vakif University

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-07-31

Primary Completion

2015-11-30

Completion

2015-12-31

Countries

• Turkey (Türkiye)

Study Locations