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Optimization of Preoperative Treatment in Locally Advanced Rectal Cancer

NCT02533271 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 600

Last updated 2021-07-16

No results posted yet for this study

Summary

The purpose of this study is to compare effectiveness of short-term radiotherapy with neoadjuvant chemotherapy(TNT group) with preoperative long-term chemoradiotherapy(CRT group) in locally advanced rectal cancer. The hypothesis is 3-year disease-free survival in TNT group was non-inferior to that in CRT group.

Conditions

  • Cancer, Rectum

Interventions

RADIATION

Short-course radiotherapy with neoadjuvant chemotherapy

Short-course radiotherapy with 4 cycles of neoadjuvant chemotherapy

RADIATION

Long-term chemoradiotherapy

Standard chemoradiotherapy

Sponsors & Collaborators

  • Chinese Academy of Medical Sciences

    lead OTHER

Principal Investigators

  • Jing Jin · Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2023-08-31
Completion
2025-08-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02533271 on ClinicalTrials.gov