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Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

NCT02527083 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2025-12-31

Study results available
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Summary

Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery. The primary aim of this study is to determine the effect of anesthesia type on long term pain after hernia surgery. In this study, patients undergoing inguinal hernia repair will be randomized to an anesthetic group, either Total Intravenous Anesthesia (TIVA) maintained with propofol or Balanced Inhaled Anesthesia (BIA) maintained with sevoflurane. This will allow us to look at any differences in short and long-term pain after hernia repair depending on type of anesthesia received.

Conditions

  • Acute Pain
  • Chronic Pain
  • Hernia
  • Anesthesia, Intravenous
  • Anesthesia, Intratracheal

Interventions

DRUG

Propofol

DRUG

Sevoflurane

DRUG

Remifentanil

DRUG

Ketamine

Sponsors & Collaborators

  • VA Pittsburgh Healthcare System

    lead FED

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2019-06-30
Completion
2019-06-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02527083 on ClinicalTrials.gov