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Esophageal Atresia: Metaplasia, Barrett

NCT02495051 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2015-07-13

No results posted yet for this study

Summary

The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.

Conditions

  • Gastroesophageal Reflux
  • Esophagus, Barrett

Interventions

PROCEDURE

esophageal biopsies

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Frédéric Gottrand, MD, PhD · University Hospital, Lille

Eligibility

Min Age
15 Years
Max Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-02-28
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • Belgium
  • Canada
  • France
  • Luxembourg

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02495051 on ClinicalTrials.gov