MedTrace Logo

Severe and Cerebral Malaria Investigated Through Host Metabolomics

NCT02451904 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 840

Last updated 2018-06-20

No results posted yet for this study

Summary

* The aim is to describe disease mechanisms of severe and cerebral malaria and identify new targets for adjunctive therapies.
* Despite treatment between 10-30% of patients with severe malaria die.
* Metabolic acidosis and cerebral malaria are major complications associated with mortality across all age groups. Still, their underlying pathogenesis remains incompletely understood.
* Using a metabolomics approach, this study aims to characterise the spectrum of acids accumulating during acidosis, and investigate patterns of metabolic dysregulation associated with coma and seizures.

Conditions

  • Severe Malaria

Interventions

OTHER

Observation

Sponsors & Collaborators

  • Chittagong Medical College and Hospital

    collaborator OTHER

  • University of Oxford

    lead OTHER

Principal Investigators

  • Prof. Arjen M. Dondorp, MD · Mahidol Oxford Tropical Medicine Research Unit

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2017-09-30
Completion
2017-09-30

Countries

  • Bangladesh

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02451904 on ClinicalTrials.gov