Two-field Versus Three-field Lymphadenectomy in Thoracic Esophageal Carcinoma Without Cervical Lymph Node Involvement

Summary

The purpose of this study is to compare the lymph node dissection results and prognosis in thoracic esophageal carcinoma patients without cervical lymph node involvement by preoperative CT and/or ultrasound treated by two-field lymphadenectomy or three-field lymphadenectomy.Another purpose of this study is to clarify whether the lymph node along the right recurrent laryngeal nerve can be taken as the sentinel lymph node which is able to indicate neck lymph node metastasis and necessity for three-field lymphadenectomy.

Conditions

• Esophageal Cancer

Interventions

PROCEDURE

Two-field lymphadenectomy

Thoracic-upper abdominal two-field lymphadenectomy

PROCEDURE

Three-field lymphadenectomy

Cervical-thoracic-upper abdominal three-field completely lymphadenectomy

Sponsors & Collaborators

• Peking University Cancer Hospital & Institute

  collaborator OTHER

• Henan Cancer Hospital

  collaborator OTHER_GOV

• Hebei Medical University Fourth Hospital

  collaborator OTHER

• Sichuan Cancer Hospital and Research Institute

  collaborator OTHER

• Fujian Cancer Hospital

  collaborator OTHER_GOV

• Liaoning Cancer Hospital & Institute

  collaborator OTHER

• Zhejiang Cancer Hospital

  collaborator OTHER

• Tongji Hospital

  collaborator OTHER

• Tang-Du Hospital

  collaborator OTHER

• Shanghai Chest Hospital

  collaborator OTHER

• Chinese Academy of Medical Sciences

  lead OTHER

Principal Investigators

• Jie He, MD,PhD · Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-01-31

Primary Completion

2017-09-30

Completion

2019-12-31

Countries

• China

Study Locations