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Influence of Edoxaban on Coagulability and Thrombin Generation: An in Vitro Study Focusing on Thrombelastography

NCT02448901 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2015-05-20

No results posted yet for this study

Summary

The influence of different doses of edoxaban on physical characteristics of the clot and thrombin generation kinetics in blood samples will be studied by in vitro spiking of blood samples collected from patients treated for heart failure (with and without hypercoagulability) and from healthy volunteers (with and without hypercoagulability). This in vitro experiment will help us to:

(i) detect qualitative anticlotting properties of edoxaban. (ii) quantify the anticlotting properties of edoxaban.

Conditions

Interventions

DRUG

Edoxaban

In vitro study. Various concentrations of Edoxoban added to blood sample and tested

Sponsors & Collaborators

Principal Investigators

  • paul gurbel, MD · Sinai Center for Thrombosis Research

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2016-02-29
Completion
2016-03-31

Countries

  • United States

Study Locations

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Diseases
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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02448901 on ClinicalTrials.gov