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Cutaneous Prostaglandin Application: Nail Growth, Nail Brittleness, and Eye Pressure

NCT02448043 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2019-12-13

Study results available
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Summary

Topical prostaglandin agents are used to help reduce eye pressure in glaucoma patients. Bimatoprost (Lumigan 0.01%) is such an agent (Allergan, Inc.). Several of our patients on bimatoprost and an observational study of patients on bimatoprost in another center reported that fingernails grew longer and became less brittle using the topical eye drops to the eyes. The purpose of the double-blinded study is to determine whether the application of the eye drops directly to the proximal nail fold of one hand using the opposite hand as a control will result in longer nails, less brittle nails, and reduced eye pressures should any of the medication be absorbed into the systemic circulation.

Conditions

  • Nail Growth Cessation
  • Intraocular Pressure

Interventions

DRUG

Bimatoprost 0.01%

Bimatoprost drops added to the proximal nail folds of the randomized study hand digits two times per day for 30 days

OTHER

Placebo: saline

Placebo drops added to the proximal nail folds of the hand digits opposite the study hand two times per day for 30 days

Sponsors & Collaborators

Principal Investigators

  • David J Palmer, MD · Northwestern University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-04
Primary Completion
2016-05-06
Completion
2016-05-06

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02448043 on ClinicalTrials.gov