MedTrace Logo

Activation of A-delta-fibres and C-fibres in a First Degree Thermal Injury in Volunteers

NCT02442726 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2015-12-03

No results posted yet for this study

Summary

The aim of this study is to measure reaction times and thermal detection thresholds to CO2 laser stimulation of the skin, before and after a first degree thermal injury, in the primary and secondary hyperalgesia area, in order to investigate whether different nerve-fiber classes are activated in the post-injury phase. The study results are expected to uncover existence of a peripheral inflammatory input contributing to secondary hyperalgesia.

Conditions

  • Healthy Subjects

Interventions

DEVICE

CO2-Laser stimulation (Laser Stimulation Device, SIFEC)

Laser stimuli are evenly applied in 15 spots (each 6 mm in diameter) in the primary hyperalgesic zone (application zone of the contact thermode) and in the secondary hyperalgesic zone (1 cm outside the application zone of the contact thermode).

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Principal Investigators

  • Mads U Werner, MD, DMSc · Neuroscience Center, Copenhagen University Hospital, Denmark

  • Ron Kupers, MSc · Panum Institute, Copenhagen University, Denmark

  • Henrik Kehlet, MD, DMSc · JMC, Copenhagen University Hospital, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2015-09-30
Completion
2015-11-30

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02442726 on ClinicalTrials.gov