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Analysis of Viral Infections' Exposition Preceding the Type 1 Diabetes (T1D) Diagnostic in Children of the Isis-Diab Cohort. Search for Explanations of of the Disease's Early Onset

NCT02425410 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 2000

Last updated 2016-06-28

No results posted yet for this study

Summary

The purpose of this study is to investigate viral factors determining the early onset of T1D. Thanks to the quantification of viral exposures of T1D patients before the disease onset with questionnaires and environmental databases analyses, and through whole genome association studies of these patients, investigators could attempt to identify gene-virus interactions determining the age of T1D onset.

Conditions

Interventions

OTHER

Collect of data on viral environment of T1D patients

Questionnaires on viral events during mother's pregnancy and patient's childhood, health book copies, addresses' geolocation, quantification of viral exposures using Sentinel Network data

GENETIC

Collect of blood samples for DNA extraction and genetic characterization (GWAS)

Collect of blood samples for DNA extraction and genetic characterization (GWAS) on Illumina platform (Centre National de Genotypage)

Sponsors & Collaborators

  • Centre National de Génotypage

    collaborator OTHER

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Alain-Jacques Valleron, PhD · Institut National de la Santé Et de la Recherche Médicale, France

  • Pierre Bougnères, MD, PhD · Inserm U986 / Pediatric endocrinology department of the Bicêtre Hospital (AP-HP)

Eligibility

Min Age
6 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2010-03-31
Primary Completion
2017-12-31
Completion
2018-06-30

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02425410 on ClinicalTrials.gov