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Therapeutic Use of Ultrasound in Acute Coronary Artery Disease

NCT02410330 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2021-12-08

No results posted yet for this study

Summary

In acute coronary artery disease, pre-clinical studies have indicated that, during a continuous infusion of intravenous perfluorocarbon containing microbubbles, the ultrasonic power delivered from a diagnostic ultrasound transducer is capable of restoring microcirculatory flow and improving epicardial recanalization rates obtained by conventional therapy, a process known by Sonothrombolysis. The investigators proposed to examine the feasibility, safety and efficacy of such an ultrasound guided approach in 100 patients with ST segment elevation myocardial infarction (STEMI).

Conditions

  • Acute Myocardial Infarction

Interventions

PROCEDURE

Therapeutic ultrasound with 20 usec

A custom designed high mechanical index (MI) impulses at 4-20 usec and \>1.0 mechanical index designed for the 1.7 MHz S5-1 transducer

PROCEDURE

Repeated diagnostic high mechanical index

Repeated diagnostic high mechanical index impulses (all \<2 usec pulse duration; MI=1.0) whenever very low mechanical index perfusion imaging detected microbubbles within the microvasculature

Sponsors & Collaborators

  • University of Nebraska

    collaborator OTHER

  • University of Sao Paulo General Hospital

    lead OTHER

Principal Investigators

  • Wilson Mathias Jr, MD · Heart Institute - University of São Paulo Medical School

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2020-01-31
Completion
2020-01-31

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02410330 on ClinicalTrials.gov