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Bronchial Inflammation and Hyperresponsiveness After Oil Supplementation

NCT02410096 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 73

Last updated 2016-09-05

No results posted yet for this study

Summary

The purpose of this study is to investigate the bronchial inflammation and hyperresponsiveness after oil supplementation. Before and after oil supplementation the investigators measure decrease in lung function after exercise-challenge in a cold chamber and increase of inflammatory markers in the blood.

Conditions

  • Exercise-induced Asthma

Interventions

OTHER

Exercise challenge in a cold chamber

Exercise challenge is defined as running on a treadmill for 6-8 minutes on submaximal work load in a cold chamber.

OTHER

Methacholine challenge

Nebulized metacholine administered at following doses: 0,01mg, 0,1mg, 0,4mg, 0,8mg und 1,6mg

DIETARY_SUPPLEMENT

Oil supplementation verum

Patients and subjects will take double blind an oil supplementation with middle-chain and polyunsaturated fatty acids for four weeks

DIETARY_SUPPLEMENT

Oil supplementation placebo

Patients and subjects will take double blind sunflower oil for four weeks

Sponsors & Collaborators

  • Johann Wolfgang Goethe University Hospital

    lead OTHER

Principal Investigators

  • Johannes Schulze, MD · Johann Wolfgang Goethe University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
12 Years
Max Age
44 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-04-30
Primary Completion
2016-02-29
Completion
2016-07-31

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02410096 on ClinicalTrials.gov