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Scrub Typhus Pediatric Immunology Study

NCT02398162 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 170

Last updated 2018-09-20

No results posted yet for this study

Summary

This is an observational study of the natural immune response to scrub typhus in patients recruited from Chiangrai Prachanukroh Hospital, N-Thailand. Febrile patients with a positive IgM rapid diagnostic test will be asked if they wish to take part in a study to improve the understanding of how the body responds to scrub typhus. Blood samples will be collected from each participant ("STP", n=60) at baseline (the day of presentation to hospital), 2 weeks later in hospital, 12 weeks after baseline at the clinic visit and 1 year later. Data on clinical presentation and relapses will be recorded. Control subjects are scrub typhus exposed patients from a rural village in the caption area of Prachanukroh Hospital ("STE", n=80; approx. 40 children and 40 adults), and healthy adults blood donors from Bangkok ("STH" n=30) - these subjects will be enrolled for one single blood sample. The study team will also collect eschar swab specimens from STP group and a non-invasive specimen of the dark crust on the day of enrollment.

Funder: Li Ka Shing Foundation \[Grant C13004\]

Conditions

  • Scrub Typhus

Interventions

PROCEDURE

Multi Blood Collections

At baseline (the day of presentation to hospital), 2 weeks, 12 weeks and 1 year later.

PROCEDURE

Single Blood Collection

On the enrollment day

Sponsors & Collaborators

  • Li Ka Shing Foundation

    collaborator OTHER

  • Mahidol University

    collaborator OTHER

  • Chiangrai Prachanukroh Hospital

    collaborator OTHER

  • University of Oxford

    lead OTHER

Principal Investigators

  • Dr.Daniel Paris, MD · Mahidol Oxford Tropical Medicine Research Unit

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-15
Primary Completion
2017-10-17
Completion
2017-10-17

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02398162 on ClinicalTrials.gov