Anti-GPC3 CAR T for Treating Patients With Advanced HCC
NCT02395250 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 13
Last updated 2019-08-28
Summary
The purpose of this study is to determine whether autologous T cells bearing chimeric antigen receptor that can specifically recognize glypican-3 (GPC3) is safe and effective for patients with relapsed or refractory hepatocellular carcinoma (HCC).
Conditions
Interventions
- BIOLOGICAL
-
anti-GPC3 CAR T
Sponsors & Collaborators
-
RenJi Hospital
lead OTHER
Principal Investigators
-
Bo Zhai, MD · Renji
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-03-31
- Primary Completion
- 2016-06-30
- Completion
- 2018-11-30
Countries
- China
Study Locations
More Related Trials
-
CAR - γ δ T Cells in the Treatment of Relapsed and Refractory CD7 Positive T Cell-derived Malignant Tumors
NCT04702841 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
CAR-T for R/R B-NHL
NCT03196830 ·Status: UNKNOWN ·Phase: PHASE2
-
CD7 CAR-T Combined With Autologous Hematopoietic Stem Cell Transplantation
NCT07117305 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART)
NCT02862704 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Adoptive Transfer of Specific HCC Antigens CD8+ T Cells for Treating Patients With Relapsed/Advanced HCC
NCT03175705 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-CD30 CAR-T Therapy in Patients With Refractory/Relapsed Lymphocyte Malignancies
NCT04008394 ·Status: UNKNOWN ·Phase: PHASE1
-
Clinical Trial of Autologous CD19 CAR-T Cells (CNCT19) Therapy for Advanced Hepatocellular Carcinoma
NCT06676982 ·Status: RECRUITING ·Phase: PHASE1
-
Safety and Efficacy Evaluation of IM83 CAR-T Cells for Patients With Advanced Liver Tumors
NCT05123209 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-CD7 CAR-T Cell Therapy for Relapse and Refractory CD7 Positive T Cell Malignancies
NCT05290155 ·Status: COMPLETED ·Phase: PHASE1
-
CAR T Cells in Treating Patients With Malignant Gliomas Overexpressing EGFR
NCT02331693 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-GPRC5D CAR-T Cells (CT071) in Participants With RRMM or RRpPCL
NCT06333509 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Ori-C101Chimeric Antigen Receptor (CAR) Modified T Cells for the Treatment of HCC
NCT05652920 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART133
NCT02541370 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc
NCT05366179 ·Status: RECRUITING ·Phase: PHASE1
-
Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies
NCT03638206 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of CCT301-59 CAR T Therapy in Adult Subjects With Recurrent or Refractory Solid Tumors
NCT03960060 ·Status: TERMINATED ·Phase: PHASE1
-
Novel Autologou CAR-T Therapy for Relapsed/Refractory B Cell Lymphoma
NCT03258047 ·Status: UNKNOWN ·Phase: PHASE2
-
CD70 Targeted CAR-T Cells in CD70 Positive Relapsed/Refractory Lymphoma
NCT05948033 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Gynecologic Cancer
NCT06215950 ·Status: RECRUITING ·Phase: PHASE1
-
Allogeneic Gamma-delta T Cells Combined With Targeted Therapy and Immunotherapy in a Phase 1 Clinical Trial of Hepatocellular Carcinoma Resistant to PD-1 Monoclonal Antibody
NCT06364800 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
Treatment of Relapsed and/or Chemotherapy Refractory CD33 Positive Acute Myeloid Leukemia by CART-33
NCT01864902 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19-CART in the Treatment of R/R CD19 Positive Non-Hodgkin's Lymphoma
NCT04237428 ·Status: UNKNOWN ·Phase: NA
-
To Assess Safety, Tolerability, and Efficacy of Anti-GPRC5D-CD19-CAR-T in Relapsed/Refractory Multiple Myeloma
NCT06298266 ·Status: NOT_YET_RECRUITING ·Phase: EARLY_PHASE1
-
CD70 Targeted CAR-T Cells in CD70 Positive Advanced/Metastatic Solid Tumors
NCT05947487 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
CD276 CAR-T for Patients With Advanced CD276+ Solid Tumors
NCT04691713 ·Status: UNKNOWN ·Phase: NA