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Assessing Cognitive fUnction and MEasuring the Cerebral circulatioN on HaemoDialysis

NCT02393222 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 97

Last updated 2015-03-19

No results posted yet for this study

Summary

Stroke disease and cognitive impairment are common in patients established on haemodialysis (HD) for end-stage renal disease (ESRD). Further, initiation of HD appears to transiently increase the risk of stroke. The mechanism by which this occurs is not known.

Using ultrasound, patient questionnaires and brain MRI our study will observe changes in cognition and cerebral blood flow whilst receiving HD compared to a non-dialysis day. Transient clinical and ultrasound alterations will be correlated to radiographic changes in cerebral perfusion and structure on MRI to determine the underlying mechanism for the increased stroke risk. The investigators will observe this effect in the immediate and longer term (12 months observation).

A greater understanding will allow development of effective preventive strategies.

Conditions

  • End-Stage Renal Disease
  • Stroke
  • Cognition Disorders

Interventions

OTHER

Observing effect of routine HD

Observing effect of routine HD via transcranial doppler, neurocognitive questionnaires and (in some) brain MRI

Sponsors & Collaborators

  • NHS Greater Glasgow and Clyde

    lead OTHER

Principal Investigators

  • Mark D Findlay, MBChB · University of Glasgow

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2016-08-31
Completion
2017-08-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02393222 on ClinicalTrials.gov