Prevention of Nosocomial Bacteremia Among Zambian Neonates

Summary

The purpose of this study is to estimate the burden of disease, identify risk factors associated with nosocomial bacteremia among neonates and assess the efficacy of low-cost measures targeted to known and suspected nosocomial BSI (bloodstream) risk factors, the investigators propose to study the impact of a novel package of infection control interventions on nosocomial bacteremia and mortality among neonates at a tertiary care center in sub-Saharan Africa.

Conditions

• Neonatal Sepsis
• Neonatal Mortality

Interventions

DRUG

Chlorhexidine gluconate (CHG)

All enrolled neonates admitted to the NICU during the implementation and intervention periods will undergo CHG bathing (sparing head and face) at the time of admission at and thereafter once weekly.

BEHAVIORAL

Hand hygiene (HH)

Alcohol hand rub will be produced in the hospital pharmacy and will be readily available in the NICU (via wall-mounted dispensers) throughout the intervention period. Hand hygiene among NICU physicians and nurses will actively be promoted through the intervention period.

BEHAVIORAL

Infection control training

All NICU healthcare workers will receive infection prevention training which will involve structure training on HH, universal precautions, neonatal skin antisepsis and peripheral IV placement and line care.

OTHER

Infection control reminders via SMS text

Infection control practice reminders will be sent to NICU healthcare workers on a daily basis via SMS messages.

Sponsors & Collaborators

• University Teaching Hospital, Lusaka, Zambia

  collaborator OTHER

• Zambia Center for Applied Health Research and Development

  collaborator OTHER

• Children's Hospital of Philadelphia

  collaborator OTHER

• Boston University

  lead OTHER

Principal Investigators

• Davidson H Hamer, MD · BU School of Medicine

Study Design

Allocation

NA

Purpose

PREVENTION

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

1 Hour

Max Age

28 Days

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-09-01

Primary Completion

2017-04-15

Completion

2017-07-31

Countries

• Zambia

Study Locations