Hypofractionated Loco-regional Adjuvant Radiation Therapy of Breast Cancer Combined With a Simultaneous Integrated Boost

Summary

The purpose of the study is to investigate the difference in late radiation morbidity between hypofractionated and normofractionated loco-regional breast irradiation irrespective of mastectomy or lumpectomy. In patients who a candidates for a boost, the boost will be provided as a simultaneous integrated boost.

Conditions

• Lymphedema
• Fibrosis

Interventions

RADIATION

Loco-regional RT

Sponsors & Collaborators

• Danish Cancer Society

  collaborator OTHER

• Danish Breast Cancer Cooperative Group

  lead OTHER

Principal Investigators

• Lars Stenbygaard, MD · Aalborg University Hospital

• Troels Bechmann, MD,PhD · Vejle Hospital

• Mette Nielsen, MD · Odense University Hospital

• Birgitte Offersen, MD · Aarhus University Hospital

• Hanne Nielsen, MD · Aarhus University Hospital

• Claus Kamby, MD · Rigshospitalet, Denmark

• Sami Al-Rawi, MD · Naestved Hospital

• Mechthild Krause, MD · Technische Universität Dresden Klinik und Poliklinik für Strahlentherapie und Radioonkologie

• Andreas Schreiber, MD · Praxis für Strahlentherapie, Dresden

• Ingvil Mjaaland, MD · Stavanger Hospital

• Tanja Marinko, MD · Institute of Oncology Ljubljana

• Carine Kirkove, MD · Radiotherapy Department Université Catholique de Louvain, Cliniques Universitaires St-Luc, Brussels

• Egil Blix, MD · University Hospital of North Norway, Tromsoe

• Unn-Miriam Kasti · Kristiansand Hospital, Norway

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-03-31

Primary Completion

2021-07-01

Completion

2032-07-01

Countries

• Denmark

Study Locations