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Does Terlipressin Improve Renal Outcome After Liver Surgery

NCT02368249 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2017-05-05

No results posted yet for this study

Summary

The investigators aim to address whether terlipressin improves the renal outcome after liver surgery. Therefore the investigators are planning to conduct a double-blinded randomized control trial. The investigators will randomize patients undergoing any kind of liver surgery and being at increased moderate to high risk for post-operative acute renal failure into a control group receiving post- operative a placebo or into a group receiving post-operatively terlipressin in combination with human albumin.

Conditions

Interventions

DRUG

Terlipressin

Patients are receiving a post-operative intravenous terlipressin treatment in association with human albumin to preserve the renal function

DRUG

Placebo

Patients are receiving a post-operative intravenous Ringer's lactate solution

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Pierre-Alain Clavien, MD PhD · Departement of Visceral and Transplantation Surgery Zurich

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-31
Primary Completion
2025-02-28
Completion
2025-02-28

Countries

  • Switzerland

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02368249 on ClinicalTrials.gov