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The Challenge of Obtaining Qualitative Bacterial Cultures in Non-expectorating Cystic Fibrosis Patients

NCT02363764 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 175

Last updated 2016-10-04

No results posted yet for this study

Summary

Accurate identification of lower respiratory tract pathogens is standard of care in the management of CF patients and it is therefore recommended to perform regular bacterial cultures, at least once a year, but some even recommend monthly cultures. This can be done through different methods, of which sputum and bronchoalveolar lavage (BAL) are the gold standard. However, BAL is an invasive method, not designated to repeat monthly. Therefore, the diagnosis of lower respiratory tract infections can be challenging in the non-expectorating CF patient. Other methods, such as induced sputum (IS), cough swabs and nasal swabs, have been developed to obtain bacterial cultures in these patients. Studies have investigated the reliability of these different sampling methods, however, with controversial conclusions.

Conditions

Interventions

PROCEDURE

Nasal swab

Will be obtained by the physiotherapist in: * Expectorating CF patients * Non-expectorating CF patients * Bronchoscopy CF patients

PROCEDURE

Cough swab

Will be obtained by the physiotherapist in: * Expectorating CF patients * Non-expectorating CF patients * Bronchoscopy CF patients

PROCEDURE

Spontaneous expectorated sputum

Will be obtained by the physiotherapist in: \- Expectorating CF patients

PROCEDURE

Induced sputum

Will be obtained by the physiotherapist in: * Non-expectorating CF patients * Bronchoscopy CF patients

PROCEDURE

Bronchoalveolar lavage

Will be obtained by the pulmonologist in: \- Bronchoscopy CF patients

OTHER

Questionnaire

Completing questionnaire on acceptability of different sampling methods by patients \>6 years of age

Sponsors & Collaborators

  • Universitair Ziekenhuis Brussel

    lead OTHER

Principal Investigators

  • Anne Malfroot, MD, PhD · Universitair Ziekenhuis Brussel - Cystic Fibrosis Clinic

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-01-31
Primary Completion
2016-08-31
Completion
2016-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02363764 on ClinicalTrials.gov