Endostar Combination With Chemotherapy and EGFR-TKI in Lung Cancer Rechallenging Treatment After Acquired Resistance.
NCT02350361 · Status: UNKNOWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2015-01-29
Summary
Here we are going to find a method by using available multiple drugs including angiogenesis medicine - Endostar to treat lung cancer patients who acquired resistence from EGFR-TKI but have responsed to it before.
Conditions
Interventions
- DRUG
-
Recombinant human endostatin
Recombinant human endostatin 7.5mg/m2
- DRUG
-
Placebo
Sponsors & Collaborators
-
Peking University Third Hospital
lead OTHER
Principal Investigators
-
Li Liang, MD · Peking University Third Hospital
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-01-31
- Primary Completion
- 2015-07-31
- Completion
- 2016-03-31
Countries
- China
Study Locations
More Related Trials
-
EGFR-TKI Combined With Concurrent or Sequential Chemotherapy for Patients of Gradual Progression
NCT03544814 ·Status: COMPLETED ·Phase: PHASE2
-
First-Line Treatment of Advanced Non-Small-Cell Lung Cancer With Negative Driver Gene: a Multicenter, Single-Arm Trial
NCT05574998 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer
NCT06755684 ·Status: RECRUITING ·Phase: PHASE2
-
Rh-endostatin Combined With Chemotherapy and Pembrolizumab for Advanced NSCLC
NCT04094909 ·Status: UNKNOWN ·Phase: PHASE2
-
Ensartinib After Chemoradiotherapy in Stage III ALK-Mutated NSCLC
NCT07235306 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
The Efficacy and Safety of Ensartinib As Adjuvant Therapy in Stage I ALK-positive NSCLC Patients with High Risk Factors
NCT06772610 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Adjuvant Treatment Based on MRD for EGFR Mutant NSCLC
NCT05536505 ·Status: RECRUITING ·Phase: PHASE2
-
Chemotherapy and Erlotinib for Lung Cancer With Low Abundance Epidermal Growth Factor Receptor Mutation
NCT02095782 ·Status: TERMINATED ·Phase: PHASE2
-
Local Injection and Systemic Therapy in the Treatment of NSCLC.
NCT06618391 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
β-elemene Combine With EGFR-TKI for Advanced EGFR-TKI-resistant NSCLC
NCT03123484 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Ensartinib as Neoadjuvant Therapy for Patients With ALK Positive Resectable Non-Small Cell Lung Cancer
NCT05380024 ·Status: UNKNOWN ·Phase: PHASE2
-
Continuation of TKI With or Without Chemotherapy Beyond Gradual Progression
NCT01998061 ·Status: UNKNOWN ·Phase: PHASE2
-
Ensatinib in alK-positive Patients Undergoing Initial Treatment for Advanced Non-small Cell Lung Cancer
NCT05132218 ·Status: UNKNOWN
-
Intercalated Combination of Chemotherapy and Tyrosine Kinase Inhibitors as First-line Treatment for Patients With Non-Small-Cell Lung Cancer
NCT02031601 ·Status: UNKNOWN ·Phase: PHASE4
-
Adjuvant Treatment of ALK-positive Non-small Cell Lung Cancer with Ensartinib Guided by MRD
NCT06780839 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Hypofractionated Radiotherapy for Limited Metastatic NSCLC Harboring Sensitizing EGFR Mutations After First Line TKI Therapy
NCT02788058 ·Status: UNKNOWN ·Phase: PHASE2
-
Erlotinib Combined With Chemotherapy in TKI Resistant Non-Small Cell Lung Cancers
NCT02098954 ·Status: RECRUITING ·Phase: PHASE2
-
Real-world Treatment Patterns and Clinical Outcomes in EGFR-mutant Unresectable Locally Advanced NSCLC
NCT04304638 ·Status: UNKNOWN
-
EGFR-TKIs Combine Chemotherapy as First-line Therapy for Patients With Advanced EGFR Mutation-positive NSCLC
NCT02886195 ·Status: UNKNOWN ·Phase: PHASE3
-
Survival Outcome of EGFR-TKI in Uncommon EGFR Mutant Advanced NSCLC
NCT04324164 ·Status: RECRUITING
-
Induction Therapy With Intercalated Tyrosine Kinase Inhibitor (TKI) and Chemotherapy in NSCLC With Activating Epidermal Growth Factor Receptor (EGFR) Mutation in Stages II-IIIB
NCT02326285 ·Status: TERMINATED ·Phase: PHASE2/PHASE3
-
Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Combined With Early Stereotactic Body Radiation Therapy to the Primary Tumor in Advanced Non-small Cell Lung Cancer
NCT03727867 ·Status: UNKNOWN ·Phase: PHASE3
-
EGFR-TKI Resistance Profile in Chinese Patients With Advanced EGFRm+ NSCLC
NCT02988141 ·Status: UNKNOWN
-
E GFR TKI and EGF-P TI C Ombination in EGFR mutA nt NSCL C
NCT03623750 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
RT Plus EGFR-TKI for Wild-type NSCLC
NCT02738983 ·Status: UNKNOWN ·Phase: PHASE2