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Determination of Genetic Polymorphisms in Chronic Chagas Cardiomyopathy

NCT02346123 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 55

Last updated 2015-10-12

No results posted yet for this study

Summary

The purpose of this study is to analyze the influence of polymorphisms of the genes CLDN-1 (Claudina-1), LGALS3 (Lectin galactoside-binding soluble 3), SOCS3 (Suppressor of cytokine signaling 3), IL-28B (interleukin-28B), CCL5 (Chemokine C-C ligand 5) in the determination of clinical forms and in the percentage of cardiac fibrosis in patients with Chagas disease.

Conditions

  • Chagas Disease

Interventions

GENETIC

Gathering of samples of genetic material

The samples will be obtained from peripheral blood mononuclear cells and the genotyping of the polymorphisms will be done by real time PCR.

Sponsors & Collaborators

  • Hospital Sao Rafael

    lead OTHER

Principal Investigators

  • Milena BP Soares, PhD · Hospital São Rafael

  • Ricardo R dos Santos, PhD · Hospital São Rafael

  • Bruno SF Souza, MD, Msc · Hospital São Rafael

  • Gabriela S Cruz, Msc · Hospital São Rafael

  • Ticiana F Larocca, MD, Msc · Hospital São Rafael

  • Márcia MN Rabelo, MD, Msc · Hospital São Rafael

  • Luís CL Correia, MD, PhD · Hospital São Rafael

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2015-06-30
Completion
2015-06-30

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02346123 on ClinicalTrials.gov