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Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

NCT02339012 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 900

Last updated 2026-05-08

No results posted yet for this study

Summary

Background:

\- Biomarkers are substances in people s blood and tissues. They help researchers understand diseases and signs of aging. Scientists want to do more research on biomarkers to find ways to improve quality of life in old age.

Objective:

\- To learn more about biomarkers and their relationship to aging.

Eligibility:

\- Adults at least 20 years old who weigh at least 110 pounds and have a body mass index below 30. They must agree that their genetic samples can be collected, studied, and stored.

Design:

* Participants will be screened with medical history, physical exam, EKG and blood and urine tests.
* Participants will have 3-day visits. They will return every 2 years.
* All visits include:
* Blood and urine collection
* Physical performance tests
* Health questionnaires
* Memory and problem-solving tests
* Magnetic Resonance Imaging (MRI) and Computerized Tomography (CT) scans.
* Muscle metabolism/ exercise tests
* Taste strips
* Muscle and/or skin biopsies/ red light therapy
* Retinal imaging/ eye tracking
* Sleep study
* ODD visits also include:
* Cytapheresis
* Bone marrow aspirate
* EVEN visits also include:
* Hyperglycemic CLAMP
* Lumbar Puncture (LP)
* Continuous Glucose Monitor (CGM)

Conditions

  • Healthy Volunteers
  • Non-Healthy/Non-Frail
  • Frail

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    lead NIH

Principal Investigators

  • Luigi Ferrucci, M.D. · National Institute on Aging (NIA)

Eligibility

Min Age
20 Years
Max Age
120 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-15
Primary Completion
2099-12-31
Completion
2099-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02339012 on ClinicalTrials.gov