TODAY2 Phase 2 Follow-up

Summary

The primary objective of T2P2 is to track the progression of T2D and related comorbidities and complications in the TODAY cohort as they transition to young adulthood. We hypothesize that:

* Youth-onset type 2 diabetes (T2D) will progress rapidly and result in high rates of diabetes-related medical complications and comorbidities.
* The rapid rate of progression is related to increased insulin resistance characteristic of puberty, worse β-cell function, degree of glycemic control, control of non-glycemic factors, and obesity itself.

Conditions

• Type 2 Diabetes

Interventions

OTHER

TODAY cohort

This protocol is observation only and involves no intervention, care, treatment, or management.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• National Eye Institute (NEI)

  collaborator NIH

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  lead NIH

Principal Investigators

• Philip S Zeitler, MD PhD · University of Colorado Denver Children's Hospital

• Silva Arslanian, MD · University of Pittsburgh

• Sonia Caprio, MD · Yale University

• Jeanie B Tryggestad, MD · University of Oklahoma Health Science Center

• Mitchell E Geffner, MD · Children's Hospital Los Angeles

• Robin S Goland, MD · Columbia University Naomi Berrie Diabetes Center

• Lorraine L Katz, MD · Children's Hospital of Philadelphia

• Lori MB Laffel, MD · Joslin Diabetes Center

• Jane L Lynch, MD · University of Texas Health Sciences Center at San Antonio

• Siripoom V McKay, MD · Baylor College of Medicine

• Rose Gubitosi-Klug, MD · Case Western Reserve University Rainbow Babies and Children's Hospital

• David M Nathan, MD · Massachusetts General Hospital

• Sherida E Tollefsen, MD · St. Louis University

• Ruth S Weinstock, MD PhD · SUNY Upstate Medical Center

• Neil H White, MD · Washington University School of Medicine

Eligibility

Min Age

15 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-03-01

Primary Completion

2020-01-17

Completion

2020-01-17

Countries

• United States

Study Locations