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Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology

NCT02307214 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 39

Last updated 2016-04-26

No results posted yet for this study

Summary

Tako-Tsubo Cardiomyopathy (TTC) and Cardiac Syndrome X (CSX) are respectively acute and chronic cardiac conditions whose clinical presentation, mimicking the onset of acute myocardial ischemia in absence of epicardial coronary disease, has progressively gained the interest of the scientific community. However, despite significant progress, their underlying pathophysiology, which seems to evoke some similarities, still remains elusive. Endothelial dysfunction and autonomic imbalance have both been individually implied in their puzzling pathogenesis.

The investigators plan to conduct our study in a cohort of TTC patients, CSX patients and healthy volunteers with the following primary objective: to assess the response of endothelial function (through the Endopat score) to the autonomic tone activation induced by a 10-minute stress mental test. The assessment of autonomic tone during activation through the evaluation of Spontaneous BaRoreflex Sensitivity (BRS) and its correlation with endothelial function (Endopat score) will represent secondary objectives.

Our study will enroll 15 patients with TTC at least six months after the event, 15 patients with classic CSX and 15 healthy volunteers who will serve as control.

Conditions

  • Syndrome X
  • Takotsubo Cardiomyopathy

Interventions

OTHER

BaroReflex Sensitivity, endothelial function measurement

no other

Sponsors & Collaborators

  • Ospedale San Giovanni Bellinzona

    lead OTHER

Principal Investigators

  • Augusto Gallino, Prof MD · Ospedale Regionale di Bellinzona e Valli - Ospedale San Giovanni, Bellinzona

  • Mattia Cattaneo, MD · Ospedale Regionale di Bellinzona e Valli - Ospedale San Giovanni, Bellinzona

  • Alessandra Pia Porretta, MD · Ospedale Regionale di Bellinzona e Valli - Ospedale San Giovanni, Bellinzona

Study Design

Allocation
NON_RANDOMIZED
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-10-31
Primary Completion
2016-04-30
Completion
2016-04-30

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02307214 on ClinicalTrials.gov