MedTrace Logo

Maternal Microchimerism in Lymph Nodes of Infants With Biliary Atresia at Time of Kasai's Operation

NCT02292862 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 7

Last updated 2014-11-17

No results posted yet for this study

Summary

Maternal microchimerism has been discussed as an etiological mechanism in infantile (perinatal) biliary atresia (BA). In Kasai's operation (resection of the liver hilum plaque followed by hepato-portoenterostomy) surgeons frequently encounter swollen portal and mesenteric lymph nodes.

Lymph nodes were sampled during Kasai' s operation and examined for maternal DNA.

Conditions

  • Biliary Atresia

Interventions

PROCEDURE

Lymph node and blood sampling

By bipolar dissection 1 portal and 1 mesenteric lymph node are removed from the infant. Blood (1ml) is taken from mother and infant.

Sponsors & Collaborators

  • Johann Wolfgang Goethe University Hospital

    collaborator OTHER

  • Medizinische Hochschule Brandenburg Theodor Fontane

    lead OTHER

Principal Investigators

  • Carsten R Engelmann, MD, OhD · Klinikum Brandenburg

Eligibility

Min Age
4 Weeks
Max Age
5 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-11-30
Primary Completion
2013-11-30
Completion
2014-11-30

Countries

  • Germany

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02292862 on ClinicalTrials.gov