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Transdermal Vagal Stimulation for POTS

NCT02281097 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 18

Last updated 2026-03-27

No results posted yet for this study

Summary

Some patients experience high heart rates and symptoms of light-headedness, fatigue, headache during standing despite well maintained blood pressure.

These patient are disabled and can't be in upright position for a longer time. The purpose of this study is to test whether electrical stimulation of a nerve through a skin of the ear may improve heart rate response and reduce disabling symptoms.

Conditions

  • Postural Orthostatic Tachycardia Syndrome

Interventions

OTHER

Stimulation

Application of current to skin above auricular branch of vagal nerve to modulate heart rate and symptoms

OTHER

Placebo

Application of low intensive current or frequency to skin above auricular branch of vagal nerve as sham intervention

Sponsors & Collaborators

  • Vanderbilt University

    lead OTHER

Principal Investigators

  • Andre Diedrich, MD, PhD · Vanderbilt University Medical Center

  • Italo Biaggioni, MD · Vanderbilt University Medical Center

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-30
Primary Completion
2017-04-30
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02281097 on ClinicalTrials.gov