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A Prospective Investigation of Pleth Variability Index (PVI) as a Dynamic Parameter of Fluid Responsiveness in Children

NCT02276599 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 9

Last updated 2018-10-18

No results posted yet for this study

Summary

This study is designed to investigate the ability of pleth variability index (PVI) to non-invasively predict fluid responsiveness in mechanically ventilated children. Patients undergoing atrial septal defect (ASD) repair in the cardiac catheterization suite will be recruited for this study. These patients are ideal candidates because very few deviations will be made from standard clinical practice. All patients will already be under general anesthesia, mechanically ventilated, monitored with pulse oximetry, and provided with intravenous fluid to compensate for their nil per os (NPO) fluid deficit. The only deviation from clinical practice will include an abbreviated echocardiographic exam, application of the Masimo pulse oximeter, and measurement of CO via a thermodilution catheter by the interventional cardiologist.

Conditions

  • Atrial Septal Defect

Interventions

PROCEDURE

Volume expansion

Fluid bolus of 0.9% normal saline 10 mL/kg over 10 minutes

Sponsors & Collaborators

  • Brian Schloss

    lead OTHER

Principal Investigators

  • Brian Schloss, MD · Nationwide Children's Hospital

Eligibility

Min Age
1 Year
Max Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2017-07-07
Completion
2018-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02276599 on ClinicalTrials.gov