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Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Electronic Cigarettes vs Combustible Cigarettes and Nicotine Gum

NCT02269514 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2018-06-04

No results posted yet for this study

Summary

The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three electronic cigarettes versus combustible cigarettes and nicotine gum.

Conditions

  • Smoking

Interventions

OTHER

Own Brand Cigarette

combustible cigarette brand style smoked most frequently by subject

OTHER

Electronic Cigarette #1

VUSE® Digital Vapor Cigarette (original flavor, 14mg nicotine)

OTHER

Electronic Cigarette #2

VUSE® Digital Vapor Cigarette (original flavor, 29mg nicotine)

OTHER

Electronic Cigarette #3

VUSE® Digital Vapor Cigarette (original flavor, 36mg nicotine)

OTHER

Leading U.S. Nicotine Gum

4 mg nicotine polacrilex gum

Sponsors & Collaborators

  • Celerion

    collaborator INDUSTRY

  • RAI Services Company

    collaborator INDUSTRY

  • R.J. Reynolds Vapor Company

    lead INDUSTRY

Principal Investigators

  • Michael Gartner, MD · Celerion

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2015-01-31
Completion
2015-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02269514 on ClinicalTrials.gov