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Administration of Warm Blood Cardioplegia With or Without Roller Pump

NCT02248415 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2014-09-26

No results posted yet for this study

Summary

The aim of this study is to compare the effect of warm blood cardioplegia administration with and without roller pump on perioperative myocardial injury, reflected by postoperative biomarker release, in patients undergoing coronary artery bypass grafting (CABG) with a minimal extracorporeal circuit (MECC).

Conditions

  • Coronary Disease

Interventions

OTHER

No pump

In the no pump group blood cardioplegia was delivered using the arterial line pressure, created by the arterial centrifugal pump of the cardiopulmonary bypass system. Blood cardioplegia flow depended on the difference between arterial line pressure and aortic root pressure.

OTHER

Pump

In the pump group blood cardioplegia was delivered using a roller pump. The blood cardioplegia flow was given at 200 mL/min.

OTHER

Blood sample collection: after induction of anaesthesia (T0)

The following biomarkers were analysed: TnT-hs, H-FABP, NT-pro-BNP and CRP.

OTHER

Blood sample collection: after arrival at the ICU (T1)

The following biomarkers were analysed: TnT-hs, H-FABP, NT-pro-BNP and CRP.

OTHER

Blood sample collection: 4 hours in ICU (T2)

The following biomarkers were analysed: TnT-hs, H-FABP, NT-pro-BNP and CRP.

OTHER

Blood sample collection: the first postoperative day (T3)

The following biomarkers were analysed: TnT-hs, H-FABP, NT-pro-BNP and CRP.

Sponsors & Collaborators

  • St. Antonius Hospital

    lead OTHER

Principal Investigators

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2013-03-31
Completion
2013-03-31

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02248415 on ClinicalTrials.gov