Comparative Pharmacokinetics and Pharmacodynamics of Tiotropium With Ipratropium or Placebo After 19 Days of Tiotropium Treatment
NCT02172781 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2014-06-24
Summary
Comparative Pharmacokinetics and Pharmacodynamics of Tiotropium With Ipratropium or Placebo After 19 Days of Tiotropium Treatment
Conditions
- Healthy
Interventions
- DRUG
-
Ipratropium - unit dose vial
- DRUG
-
Tiotropium - inhalation capsule
- DRUG
-
Placebo matching tiotropium
- DRUG
-
Placebo matching ipratropium
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- CROSSOVER
Eligibility
- Min Age
- 40 Years
- Max Age
- 65 Years
- Sex
- MALE
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2001-01-31
- Primary Completion
- 2001-04-30
More Related Trials
-
Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Respimat Device in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NCT02175342 ·Status: COMPLETED ·Phase: PHASE2
-
Acute Bronchodilator Response of a Single Dose of Atrovent or Berotec on Top of Pharmacodynamic Steady State of Spiriva
NCT00274066 ·Status: COMPLETED ·Phase: PHASE3
-
Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two Inhalers
NCT03246581 ·Status: COMPLETED ·Phase: PHASE1
-
Tiotropium in Combination With Concomitant Cimetidine or Ranitidine in Healthy Male and Female Subjects
NCT02172417 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics of the Fixed Dose Combination of Tiotropium Plus BI 54903 Versus the Combination of the Monoproducts of Tiotropium and BI 54903 in Healthy Volunteers
NCT01309139 ·Status: COMPLETED ·Phase: PHASE1
-
Effect of Tiotropium on Airway Diameter in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NCT02172391 ·Status: COMPLETED ·Phase: PHASE3
-
Cross-over Study in Volunteers to Compare the Pharmacokinetics of Tiotropium Delivered From Test and Reference Products
NCT02676297 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluation of Tiotropium 2.5 and 5 µg Once Daily Delivered Via the Respimat Inhaler Compared to Placebo in Patient With Moderate to Severe Persistent Asthma
NCT01340209 ·Status: COMPLETED ·Phase: PHASE3
-
Tiotropium in the Treatment of the Patients With Chronic Obstructive Pulmonary Disease
NCT02177318 ·Status: COMPLETED
-
Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BEA 2180 BR in Healthy Male Subjects
NCT02263976 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety of 2 Doses of Tiotropium Via Respimat in Adult Patients With Mild Persistent Asthma
NCT01316380 ·Status: COMPLETED ·Phase: PHASE3
-
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Two Reference Products
NCT02627625 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Investigate Safety and Tolerability of BI 1744 CL in Free Dose Combination With Tiotropium Bromide Both Administered by Respimat® in Healthy Male Volunteers
NCT02259946 ·Status: COMPLETED ·Phase: PHASE1
-
Comparison of the Pharmacokinetics of Tiotropium Delivered From Test Inhaler Products With Reference
NCT03302065 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetic Study Comparing Tiotropium Easyhaler and Spiriva Handihaler
NCT03400241 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacodynamic and Pharmacokinetic Dose Ranging Study of Tiotropium Bromide Administered Via Inhalation Solution in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NCT03118765 ·Status: COMPLETED ·Phase: PHASE2
-
Tiotropium Respimat Pharmacokinetic Study in COPD
NCT01222533 ·Status: COMPLETED ·Phase: PHASE2
-
Tiotropium Bromide Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease
NCT04780984 ·Status: COMPLETED ·Phase: PHASE2
-
Effectiveness of Ipratropium Bromide in Preventing Exercise-induced Bronchoconstriction in Athletes
NCT01691079 ·Status: COMPLETED ·Phase: PHASE4
-
Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo and Salmeterol HydroFluoroAlkane (HFA) Metered Dose Inhaler (MDI) (50 mcg Twice Daily) in Patient With Moderate Persistent Asthma II
NCT01172821 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Tiotropium Inhalation Capsules on Exercise Tolerance, Daily Activity and Dyspnoea in Patients With Chronic Obstructive Pulmonary Disease (COPD) Participating in 3 Weeks of Pulmonary Rehabilitation
NCT02172508 ·Status: TERMINATED ·Phase: PHASE4
-
Bioequivalence Study of Tiotropium 18 μg Inhalation Powder, Hard Capsule With Spiriva®Handihaler® 18 μg Inhalation Powder, Hard Capsule in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NCT05986591 ·Status: COMPLETED ·Phase: PHASE3
-
An Efficacy and Safety Profile of Inhaled TV48108 in Healthy Volunteers and COPD Patients
NCT02315144 ·Status: TERMINATED ·Phase: PHASE1
-
Evaluating the Impact of Single Dose Tiotropium on Allergen-induced Early Asthmatic Response
NCT06679465 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
A Randomised, Double-blind, Crossover Study of Ba679BR Respimat in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NCT00292448 ·Status: COMPLETED ·Phase: PHASE2