Ridge Preservation With New Class of Osteoplastic Materials

Summary

Return to normal life and shortening rehabilitation period of patients after surgical removal of teeth is important and urgent social problem. In this regard, higher demands for quality of care and treatment of patients, which requires the development of new approaches to the treatment of patients, the introduction of new technologies and the associated development of new materials . Serious problem of contemporary oral and maxillo-facial surgery and dentistry is augmentation of bone defects generated during the surgical treatment of diseases and injuries of the bones. The results of surgical repair of bone defects are more dependent on the course of the process of reparative osteogenesis. Long-term periods of clinical studies indicate that reparative osteogenesis in posttraumatic bone defects is slow - months and years, and in some cases no bone defects filled with bone tissue.

This project aims at addressing the preservation of bone volume in humans after tooth extraction using biomaterials with optimum performance. The practical significance of the project is to establish an effective tissue response and, thus, possible subsequent quality installation of dental implants. The proposed solution is based on the scientific development of the operative techniques, and a comparative analysis of several classes of biomaterials (xenogenic and synthetic analogs), including the use of biological precursors of bone apatite mineralization having osteoinductive (stimulating) properties.

Conditions

• Tooth Extraction
• Atrophy of Edentulous Alveolar Ridge

Interventions

DEVICE

Octacalcium phosphate

Bone augmentation, after tooth extraction, with Octacalcium Phosphate (synthetic bone graft material) in combination with resorbable collagen membrane Bio-Gide.

DEVICE

Bio-Oss

Bone augmentation, after tooth extraction, with Bio-Oss (bovine-derived xenograft)in combination with resorbable collagen membrane Bio-Gide

DEVICE

Tricalcium phosphate

Bone augmentation, after tooth extraction, with Tricalcium Phosphate (synthetic bone graft material) in combination with resorbable collagen membrane Bio-Gide.

Sponsors & Collaborators

• Central Scientific Research Institute of Dentistry and Maxillo-facial Surgery, Moscow, Russia

  collaborator UNKNOWN

• Bionova, Skolkovo Community, Russia

  collaborator UNKNOWN

• I.M. Sechenov First Moscow State Medical University

  lead OTHER

Principal Investigators

• Anatoly Kulakov, Prof · Central Scientific Research Institute of Dentistry and Maxillo-facial Surgery

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

17 Years

Max Age

85 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-09-01

Primary Completion

2018-12-01

Completion

2019-04-01

Countries

• Russia

Study Locations