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AV Delay Optimization vs. Intrinsic Conduction in Pacemaker Patients With Long PR Intervals

NCT02154750 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2025-07-24

Study results available
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Summary

This is a randomized, prospective clinical trial to determine the effects of two different pacemaker atrioventricular delay (AV delay) settings on heart function in patients with dual chamber pacemakers implanted for symptomatic bradycardia with long PR intervals (delayed conduction between upper and lower chambers of the heart). The study will compare a long, fixed AV delay (standard) with an optimized AV delay for each individual using echocardiography (experimental).

Conditions

  • Atrioventricular Block
  • Sick Sinus Syndrome
  • Symptomatic Bradycardia
  • Cardiac Arrhythmia

Interventions

DEVICE

Long, fixed AV delay

Pacemaker will be set to a long, fixed AV delay to minimize ventricular pacing

DEVICE

Short, optimized AV delay

Pacemaker will be set to the AV delay that produces the greatest cardiac output in echocardiography for each patient enrolled.

Sponsors & Collaborators

Principal Investigators

  • Gregory K Feld, MD · UCSD Electrophysiology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-06-01
Primary Completion
2021-12-31
Completion
2021-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02154750 on ClinicalTrials.gov