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The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance

NCT02139982 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 110

Last updated 2014-08-01

Study results available
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Summary

Phase 1 Sympathetic block leads to vasodilatation and increases in blood flow. However, regional hemodynamic changes of radial and ulnar artery after specific nerve block of brachial plexus remains unclear. The aim of the study is to assess the effect of specific nerve block of brachial plexus on hemodynamics of upper extremity, and provides evidence for further research in patient undergoing microvascular surgery.

Phase 2 There is no literature about dose-finding studies of sympathetic block after brachial plexus block. Little is known regarding the relationship between concentration of local anaesthetic and vasodilation of upper extremity. The aim of this randomized, double-blind, prospective dose-response study is to determine the ED50 and ED95 of ropivacaine in sympathetic block of upper extremity after supraclavicular block

Conditions

  • Upper Limb Nerve Block

Interventions

PROCEDURE

specific nerve block

specific nerve blocks of the musculocutaneous, radial, ulnar, or median nerves at axillary region

DRUG

ropivacaine

Different concentration of ropivacaine

Sponsors & Collaborators

  • Health and Family Planning Commission of Zhejiang Province, China

    collaborator UNKNOWN

  • Wenzhou Medical University

    lead OTHER

Principal Investigators

  • Ting Li, M.D. · Wenzhou Medical University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-01-31
Primary Completion
2012-12-31
Completion
2012-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02139982 on ClinicalTrials.gov