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Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome

NCT02122328 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 642

Last updated 2025-07-20

No results posted yet for this study

Summary

The investigators hypothesize that treatment of twin-twin transfusion syndrome (TTTS) using sequential laser photocoagulation of communicating vessels (SQLPCV) over the predominant method, selective laser photocoagulation of communicating vessels (SLPCV), may provide vascular stability to the donor fetus. The primary objective is to evaluate the perinatal outcome, specifically, donor intrauterine survival of TTTS managed by SQLPCV vs. SLPCV in a prospective, randomized trial.

Conditions

  • Twin Twin Transfusion Syndrome

Interventions

PROCEDURE

Sequential laser photocoagulation of communicating vessels.

PROCEDURE

Selective laser photocoagulation of communicating vessels

Sponsors & Collaborators

  • University of Southern California

    lead OTHER

Principal Investigators

  • Ramen Chmait, MD · University of Southern California

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Max Age
55 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-06-09
Primary Completion
2023-04-30
Completion
2023-10-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02122328 on ClinicalTrials.gov