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Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis

NCT02120872 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2014-04-23

No results posted yet for this study

Summary

The purpose of the present study was to investigate the efficacy of autologous Platelet rich fibrin (PRF) or PRF and Simvastatin (SMV) with open flap debridement (OFD) in the treatment of three wall intrabony defects in comparison to OFD alone.

Conditions

  • Three Wall Intrabony Defects in Chronic Periodontitis

Interventions

DRUG

Platelet rich fibrin and simvastatin

Three wall intrabony defect sites treated with Open Flap Debridement. 0.1 mL prepared SMV gel (1.2 mg/0.1 mL) was mixed with PRF. The PRF - SMV mixture was delivered to the defect.

BIOLOGICAL

Platelet rich fibrin

Three wall intrabony defect sites treated with Open Flap Debridement. PRF was placed into the intrabony defect.

PROCEDURE

Open Flap Debridement alone

Three wall intrabony defect sites treated with Open Flap Debridement only. No PRF or SMV was delivered to the defect.

Sponsors & Collaborators

  • Government Dental College and Research Institute, Bangalore

    lead OTHER

Principal Investigators

  • Avani R Pradeep, MDS · Government Dental College and Research Institute, Bangalore

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-02-28
Primary Completion
2014-01-31
Completion
2014-01-31

Countries

  • India

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02120872 on ClinicalTrials.gov