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Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

NCT02116868 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2019-11-01

No results posted yet for this study

Summary

The purpose of this study is to determine whether analgesia guided by pupillary reflex during laparoscopic surgery is effective in opioid sparing (intraoperative remifentanil and postoperative morphine).This is a prospective, randomized, controlled study performed in two centers.

Conditions

  • Scheduled Laparoscopic Surgery

Interventions

DEVICE

Pupillometry guided analgesia (PP)

Analgesia is guided by pupillary reflex provided by the pupillometer (AlgiScan). The anesthesiologist in charge must adjust the peroperative remifentanil dose (Target controlled infusion) during surgery according to the algorithm proposed (Tailored remifentanil controlled infusion). Administration of antihypertensive drugs or vasopressors is also guided.

DRUG

Tailored remifentanil controlled infusion

The anesthesiologist in charge must adjust the peroperative remifentanil dose (Target controlled infusion) during surgery according to the algorithm proposed

DRUG

Tailored antihypertensive drug administration

Administration of antihypertensive drugs or vasopressors is guided by the results of the pupillary reflex.

Sponsors & Collaborators

  • Central Hospital, Nancy, France

    lead OTHER

Principal Investigators

  • Claude MEISTELMAN, MD., PhD. · Department of Anesthesiology and Critical Care Medicine, CHU NANCY Brabois, FRANCE

  • Philippe GUERCI, MD · Department of Anesthesiology and Critical Care Medicine, CHU NANCY Brabois, FRANCE

  • Florence VIAL, MD · Department of Anesthesiology, Maternité Régionale Universitaire, CHU NANCY, France

  • Hervé BOUAZIZ, MD., PhD. · Department of Anesthesiology, Maternité Regionale Universitaire, CHU NANCY, FRANCE

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-03-31
Primary Completion
2018-03-31
Completion
2018-04-30

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02116868 on ClinicalTrials.gov