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Association of Amino Acid Prevalence and Chronic Brain Injury

NCT02113124 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2015-12-15

Study results available
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Summary

Years after a suffering a brain injury, individuals remain in a physically and cognitively impaired state. The investigators believe that the concentrations of amino acids in the blood are chronically altered and yield negative effects on the individuals health. Preliminary data has shown significantly lower concentrations of amino acids in serum samples from the TBI population, these diminished levels of amino acids may be due to changes in the microbiome. Understanding these changes will help guide rehabilitative services for this population. Individuals with a chronic brain injury will donate samples of blood, oral tissue, and fecal matter to be compared to that of non-injured individuals. Genetic information from the hosts will be striped and discarded; participant's genetic information will not be retained. To better understand changes in the microbiome, any history of antibiotics and probiotics will be assessed.

Conditions

  • Chronic Traumatic Brain Injury

Sponsors & Collaborators

  • The Moody Foundation

    collaborator OTHER

  • Brent Masel

    lead OTHER

Principal Investigators

  • Brent E Masel, MD · Transitional Learning Center

Eligibility

Min Age
35 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-12-31
Primary Completion
2014-12-31
Completion
2014-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02113124 on ClinicalTrials.gov