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Swiss Atrial Fibrillation Cohort Study

NCT02105844 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 2415

Last updated 2025-07-09

No results posted yet for this study

Summary

Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged \>65 years will be included and followed on a yearly basis.

Yearly clinical examinations include a detailed questionnaire on personal characteristics, a resting electrocardiogram, neurocognitive function tests and questionnaires on disability and quality of life. Blood sampling and brain magnetic resonance imaging are scheduled at baseline and after 2 years of follow-up.

The main study aims of this long term prospective study are to increase our knowledge on structural brain damage and its changes over time in patients with atrial fibrillation, to gain additional insights on the incidence and underlying mechanisms of cognitive decline in patients with atrial fibrillation and to evaluate the interrelationships of structural and functional brain damage in this population.

Conditions

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • Medical Image Analysis Center (MIAC) Basel

    collaborator UNKNOWN

  • Schiller AG Baar

    collaborator UNKNOWN

  • Clinical Trial Unit, University Hospital Basel, Switzerland

    collaborator OTHER

  • Cardiovascular Research Institute (CRIB) Basel

    collaborator UNKNOWN

  • Cardiocentro Ticino

    collaborator OTHER

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Stefan Osswald, MD, Prof. · University Hospital, Basel, Switzerland

  • Michael Kuehne, MD, PD, exec. MBA · University Hospital, Basel, Switzerland

  • David Conen, MD MPH · McMaster University, Population Health Research Institute, Hamilton, Canada

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-03-31
Primary Completion
2030-03-31
Completion
2030-03-31

Countries

  • Switzerland

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02105844 on ClinicalTrials.gov